A lengthy blast of high-pressure steam is much more effective at penetrating and sterilizing things than a quick wash or wipe in ordinary hot water and disinfectant. According to one recent review by scientists from New Zealand: “Steam sterilization (autoclaving) is the most widely used method for sterilization and is considered the most ...
Get DetailsAug 05, 2016 In this type of maceration, organized drug are used. TYPES:- 1.Kinetic maceration: is carried out at room temperature, like simple maceration, the difference being that the material is kept in constant motion. 2.Vortical (turbo) Extraction:-The drug is stirred in the menstrum with a high-speed mixture or homogenizer 17.
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Get DetailsHigh-pressure homogenizers and pressure extruders operate by forcing a pressurized cell suspension through a narrow orifice valve. The valve may be a simple restricting needle valve as in the French Press or a more complex design with a combined valve seat and impact ring found in the APV Manton-Gaulin homogenizer.
Get DetailsJul 05, 2012 6.3. High Pressure Homogenization. High-pressure homogenization has been used to prepare nanosuspension of many poorly water soluble drugs. In this method, the suspension of a drug and surfactant is forced under pressure through a nanosized aperture valve of a high pressure homogenizer.
Get DetailsReduce the viscosity of the suspension by sonicating 5 min at full power with 50% duty cycle (on for 5 sec, off for 5 sec) using an ultrasonic homogenizer, as described in UNIT 6.2, step 5. 5 Unbroken cells, large cellular debris, and the inclusion body protein will be pelleted.
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